Aerosol filters have a wide range of applications, among them respirators, high volume air samplers, engine exhaust filters, clean room filters and cigarette filters. Each must meet specific requirements when subjected to specific standard test conditions. In this work, the complex process of particle-fiber interaction was studied for five different cellulose acetate filters with fiber diameters that varied from 0.1 µm to 24 µm. Four of these filters, with median fiber diameter varied 0.1-1.0 µm, were generated using electrospinning, while the one with 24 µm diameter was obtained from a regular cigarette filter. For comparison, a commercial glass fiber filter of average fiber diameter 0.5 µm was used as a control. Filtration performance was evaluated using both solid and liquid aerosols at a relatively high face velocity of 45 cm/s. Filters were evaluated in terms of overall particle penetration, MPPS, pressure drop Δp, quality factor Q, and filter clogging. Results were compared with empirical correlations to understand particle fiber interaction as a function of fiber diameter.