Flexible Octopus-Shaped Hydrogel Particles for Specific Cell Capture

Presenter: 

Lynna Chen

Authors: 

Lynna Chen, Harry Z. An, Ramin Haghgooie, Aaron T. Shank, Joseph M. Martel, Mehmet Toner, and Patrick S. Doyle

Author Affiliation: 

1 Department of Biological Engineering, MIT; 2 Department of Chemical Engineering, MIT; 3 MGH, Harvard Medical School

Abstract: 

Multi-arm hydrogel microparticles are fabricated with varying geometry to capture cells expressing epithelial cell adhesion molecule, a common marker on many circulating tumor cells. Results show that particle shape influences cell-capture efficiency due to differences in surface area, hydrodynamic effects and steric constraints. These findings can lead to improved particle design for cell separation and diagnostic applications.